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Benzalkonium chloride, a preservative used in the majority of nasal sprays and drops, has been studied in vivo in healthy human volunteers. When 0.02% benzalkonium chloride was administered, the time it took for saccharin to clear the body was slightly longer than it was after 0.9% saline (n = 27, P = 0.04, Wilcoxon test). On a double-blind basis, 65 healthy volunteers were randomized to receive saline, fluticasone propionate aqueous nasal spray, or placebo, which contained all the constituents of fluticasone aqueous spray except for the fluticasone propionate, for a period of two weeks, two puffs twice a day. Prior to this trial and again at two weeks, symptoms, acoustic rhinometry, saccharin clearance time, and ciliary beat frequency were all measured.  Fluticasone Propionate is a steroid that works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

Seasonal and perennial allergic rhinitis
Treatment and management of asthma by prophylaxis

Local common side effects of fluticasone propionate:

The nasal spray should not be used under the following conditions:
Ulcers of the nasal septum