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This combination medication is used to treat melasma on the face. Melasma is a condition of dark patchy areas on the skin, especially on the cheeks and forehead. It sometimes occurs with hormone changes. This product contains 3 different kinds of medication. Hydroquinone is a reversible skin bleaching agent. Tretinoin is a retinoid that increases skin shedding. Fluocinolone is a medium strength corticosteroid that reduces swelling, itching, and redness.This medication may improve your melasma, but it is not a cure. Continued exposure to some of the causes of melasma (such as sunlight, estrogen-type birth control hormones) may cause it to return.



  • Tell your doctor or pharmacist if you are allergic to fluocinolone/tretinoin/hydroquinone; or to other corticosteroids (such as hydrocortisone, prednisone); or to vitamin A-related drugs (such as isotretinoin); or if you have any other allergies. Inactive ingredients (such as sulfites) in this product may cause allergic reactions or other problems. For more information, consult your pharmacist.
  • During pregnancy, this medication should be used only when absolutely necessary. It could be harmful to a developing child. Discuss the risks and benefits with your doctor.
  • Tell your doctor or pharmacist about your medical history, especially if you have: asthma, open sores or broken skin (especially on the face or hands), or other skin conditions (such as eczema, or psoriasis).
  • In some cases, excessive bleaching of the skin may occur, resulting in an undesirable cosmetic effect in those with darker skin. For more information, speak with your doctor or pharmacist.
  • When these drugs are applied to the skin, it is unknown whether they pass into breast milk. Before breastfeeding, consult your doctor. In areas where this product has been used, avoid skin-to-skin contact with your infant.

Side Effects

Mild burning, stinging, redness, dryness, or acne are possible side effects. Inform your doctor or pharmacist right away if any of these side effects persist or worsen.

 Remember that your doctor has prescribed this medication because the benefit to you outweighs the risk of side effects. Many people who take this medication have no serious side effects.

 Notify your doctor immediately if you experience any of the following serious side effects: blistering, skin cracking/shedding, "spider veins" (telangiectasia), stretch marks, other skin discoloration (other than melasma), "hair bumps" (folliculitis), blue-black darkening of the skin, numbness/tingling of hands/feet, increased pain/touch sensitivity.

 It is possible that this medication will be absorbed through the skin and into the bloodstream on rare occasions. This can result in corticosteroid side effects. These side effects are more common in children and people who use this medication for an extended period of time or on large areas of the skin. If any of the following side effects occur, notify your doctor immediately: unusual/excessive tiredness, weight loss, headache, ankle/foot swelling, increased thirst/urination, vision problems